Butanamide, 2-[(2-amino-9H-purin-6-yl)thio]-N-(4-hydroxy-3-methoxyphenyl)-

Description

ENPP1 inhibitor 43 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1; K_i = 41 nM).¹ It inhibits tumor growth in an LLC1 murine lung cancer model when administered orally or intravenously at doses of 10 and 100 mg/kg, respectively.

References

1. Gangar, M., Goyal, S., Raykar, D., et al. Design, synthesis and biological evaluation studies of novel small molecule ENPP1 inhibitors for cancer immunotherapy Bioorg. Chem. 119,105549(2022).