Description
Rifabutin-d
7 is intended for use as an internal standard for the quantification of rifabutin by GC- or LC-MS. Rifabutin is a rifamycin antibiotic.
1,2 It is active against a variety of Gram-positive and Gram-negative bacteria, including 81 clinical isolates of
H. pylori (MIC
50 = 0.25 μg/ml), as well as
S. aureus,
S. pyogenes, and
C. trachomatis (MICs = 0.004, 0.005, and ~0.008 μg/ml, respectively). Rifabutin (0.5 μg/ml) is also active against 302 strains of
M. tuberculosis.
2 It inhibits protein synthesis
via inhibition of DNA-dependent RNA polymerase (RNAP) activity.
2 Rifabutin (10, 20, or 40 mg/kg) reduces the number of spleen, lung, and liver colony forming units (CFUs) in mouse models of disseminated
Mycobacterium avium complex (MAC) infection.
3 Formulations containing rifabutin have been used in the treatment of
H. pylori infection.
References
1. Heep, M., Beck, D., Bayerd?rffer, E., et al.
Rifampin and rifabutin resistance mechanism in Helicobacter pylori Antimicrob. Agents Chemother. 43(6),1497-1499(1999).
2. Kunin, C.M.
Antimicrobial activity of rifabutin Clin. Infect. Dis. 22(Supp. 1),S3-S14(1996).
3. Klemens, S.P., Grossi, M.A., and Cynamon, M.H.
Comparative in vivo activities of rifabutin and rifapentine against Mycobacterium avium complex Antimicrob. Agents Chemother. 38(2),(1994).
