Rifabutin-d
7 is intended for use as an internal standard for the quantification of rifabutin by GC- or LC-MS. Rifabutin is a rifamycin antibiotic.
1,2 It is active against a variety of Gram-positive and Gram-negative bacteria, including 81 clinical isolates of
H. pylori (MIC
50 = 0.25 μg/ml), as well as
S. aureus,
S. pyogenes, and
C. trachomatis (MICs = 0.004, 0.005, and ~0.008 μg/ml, respectively). Rifabutin (0.5 μg/ml) is also active against 302 strains of
M. tuberculosis.
2 It inhibits protein synthesis
via inhibition of DNA-dependent RNA polymerase (RNAP) activity.
2 Rifabutin (10, 20, or 40 mg/kg) reduces the number of spleen, lung, and liver colony forming units (CFUs) in mouse models of disseminated
Mycobacterium avium complex (MAC) infection.
3 Formulations containing rifabutin have been used in the treatment of
H. pylori infection.
