4-(Methylsulfonylamino)benzylaminehydrochloride

Synthesis

238427-63-9

128263-66-1

Step 4: Synthesis of 4-methanesulfonylaminobenzylcarbamate hydrochloride; To a 50 mL single-necked round-bottomed flask was added tert-butyl 4-methanesulfonylaminobenzylcarbamate (1.2 g, 4.0 mmol) and 30 mL of 1,4-dioxane. Concentrated hydrochloric acid (2 mL) was slowly added to the solution and the reaction was stirred for 4 hours at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove the solvent. The resulting solid was washed with ethyl acetate and separated by filtration through a glass filter. Finally, the collected solid was dried in air to afford the target product 4-methylsulfonylaminobenzylamine hydrochloride (0.947 g, 100% yield).

References