Synthesis
The general procedure for the synthesis of (S)-2-amino-3-(3-bromophenyl)propionic acid from (S)-3-(3-bromophenyl)-2-((tert-butoxycarbonyl)amino)propionic acid was as follows: (S)-3-(3-bromophenyl)-2-((tert-butoxycarbonyl)amino)propionic acid (5.0 g, 14.5 mmol) was suspended in a 1,4-dioxane solution of 4 M hydrochloric acid (75 mL ) and the reaction was stirred at room temperature for 16 hours. Upon completion of the reaction, the white precipitate was collected by filtration and washed with ether (Et2O) to afford (S)-2-amino-3-(3-bromophenyl)propionic acid (3.2 g, 89% yield) as a white solid, and the product did not require further purification. The nuclear magnetic resonance hydrogen spectrum (1H NMR, CDCl3) data of the product were as follows: δ 8.32 (2H, s), 7.50-7.48 (2H, m), 7.34-7.29 (2H, m), 4.22 (1H, t, J=6.2 Hz), 3.13-3.11 (2H, m).
References
[1] Patent: WO2008/47109, 2008, A1. Location in patent: Page/Page column 42
[2] Patent: WO2006/114606, 2006, A1. Location in patent: Page/Page column 61
