Thalidomide-O-PEG3-amine HCl

Uses

Thalidomide-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Biological Activity

Thalidomide 4'-ether-PEG3-amine is a functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a short PEG linker ready for conjugation to a target protein ligand. This product has been recently renamed. The previous name for this product was Thalidomide - linker 11

IC 50

Cereblon

storage

Store at -20°C

References

[1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.[Content Brief] DOI:10.1038/nature13527