Manufacturing Process
2-Aminomethyl-1,4-benzodioxane (17 g) and β-methoxyethoxy ethyl chloride
(7 g) were heated at 160°C for 2 hours. The reaction mixture was cooled and
chloroform (30 ml) and a solution of potassium carbonate (7 g) in water (20
ml) added thereto.The chloroform layer was removed and the aqueous layer
extracted twice with chloroform (10 ml each time). The chloroform extracts
were combined and dehydrated over anhydrous sodium sulfate. Filtration,
followed by distillation gave 2-(β-methoxyethoxyethyl)amino-methyl-1,4-
benzodioxane (yield 7.7 g) as a pale yellow oil boiling at 180-186°C/11.5 mm.
The base was converted to a white hydrochloride having a melting point of 104-106°C by the addition of alcoholic hydrogen chloride to an ether solution
of the base and isolation of the salt which separated.
