Description
A blue dye used in the assessment of
hepatobiliary dysfunction. The concentration in plasma is
monitored since dye removal from the blood is delayed in
hepatic dysfunction. Experimentally the appearance of sulfobromphthalein in the bile can also be measured.
Chemical Properties
White, crystalline powder; odorless; bit-
ter taste. Hygroscopic; soluble in water; insoluble
in alcohol and acetone.
Uses
Medicine (diagnostic aid).
Uses
Sulfobromophthalein disodium salt hydrate has been used as a positive control to study the interaction of 11-keto-β-boswellic acid (KBA) and 3-acetyl-11-keto-β-boswellic acid (AKBA) with organic anion transporter OATP1B3.
Biochem/physiol Actions
Sulfobromophthalein (BSP) is a high affinity organic ion substrate for organic anion transporting polypeptides (OATPs) and has been used as a substrate for multidrug resistance associated protein 2 (Mrp2). BSP is transported into hepatocytes by OATPs and, after conjugation to glutathione, is excreted into bile by Mrp2. It was found to inhibit the aldo-keto reductase ARK1C20.
