Uses
Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an Kd value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1[1].
Definition
ChEBI: Triptohypol C is a pentacyclic triterpenoid with formula C29H40O4, originally isolated from the root bark of Tripterygium regelii. It has a role as a plant metabolite and an apoptosis inducer. It is a pentacyclic triterpenoid, a monocarboxylic acid and a member of benzenediols.
in vivo
Caused 3.12% apoptosis in cells, which was less cytotoxic than Tripterin (>10%).
| Animal Model: | Zebrafish[1] |
| Dosage: | 0.5μM, 1μM and 1.25μM |
| Administration: | 72 h |
| Result: | Had less effect than Tripterin on the death rate and malformation of zebrafish either at a concentration of 1.25μM for 24h or at a concentration of 0.5μM for 72h. |
References
[1] Chen Z, et al. SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway. Eur J Med Chem. 2019 Sep 1;177:171-187. DOI:
10.1016/j.ejmech.2019.05.009
