Synthesis
The resulting oxime was added to a 100 mL three-necked flask with 66 mL of 15% NaOH solution, and 6.50 g of Raney nickel was added slowly in batches at a controlled temperature of 32C, and the reaction was heated to reflux at 100 DD for 15 h. After the reaction was complete, the reaction was cooled to room temperature, and the filtration was carried out under vacuum. A small amount of water (about 5mL) was measured to wash the filtrate and the filtrate was retained. Then the filtrate was extracted with 165mL of ethyl acetate in three portions, retaining the organic oil phase layer, hydrochloric acid adjusted the pH to 1-2, and anhydrous sodium sulfate was added to it, and it was left to dry for 2 h. Vacuum filtration was carried out to obtain 3-bromo-4-fluorobenzylamine hydrochloride.
