Uses
3-Pyrrolidinecarboxylic acid is used as a catalyst in asymmetric Mannich-type reactions of unmodified ketones and aldehydes with imines, including reactions utilizing potassium carbonate as an additive, to achieve preferential formation of anti-isomers with high diastereoselectivity and enantioselectivity[1].
References
[1] Garg, Y., Tanaka*, F. (2020). Enantioselective Direct anti-Selective Mannich-type Reactions Catalyzed by 3-Pyrrolidinecarboxylic Acid in the Presence of Potassium Carbonate: Addition of Potassium Carbonate Improves Enantioselectivities.
Organic Letters,
22 11, 4542–4546.
https://doi.org/10.1021/acs.orglett.0c01561
