E3 ligase Ligand-Linker Conjugates 12
- Product NameE3 ligase Ligand-Linker Conjugates 12
- CAS1797406-80-4
- CBNumberCB24694700
- MFC30H43N7O7S
- MW645.78
- MDL NumberMFCD31807299
- MOL File1797406-80-4.mol
Chemical Properties
storage temp. | 2-8°C |
E3 ligase Ligand-Linker Conjugates 12 Price
Product number | Packaging | Price | Product description | Buy |
---|---|---|---|---|
Sigma-Aldrich 904651 | 50mg | $549 | (S,R,S)-AHPC-PEG3-azide
≥95%
|
Buy |
Iris Biotech GmbH PTC1610 | 50mg | $634.5 | (S,R,S)-AHPC-PEG3-N3 |
Buy |
E3 ligase Ligand-Linker Conjugates 12 Chemical Properties,Usage,Production
Uses
Protein degrader builiding block (S,R,S)-AHPC-PEG3-Azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Preparation Products And Raw materials
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