1,1'-Carbonyl-di(1,2,4-triazole)

Chemical Properties

1,1'-Carbonyl-di(1,2,4-triazole) is beige powder

Uses

1,1'-Carbonyl-di(1,2,4-triazole) is used in epoxidation reactions in organic synthesis. It is useful in preparing acyl triazolides from carboxylic acids. 1'-Carbonyl-di(1,2,4-triazole) is a reagent for peptide synthesis; preparation of thiol or selenol esters.

Uses

N,N''-Carbonyl-di-(1,2,4-triazole) is used in preparation of the bridged cycloformylpyridine derivative and their medical applications.

reaction suitability

reaction type: Carbonylations

Synthesis

1,1'-Carbonyl-di(1,2,4-triazole) is preparate from triazole and phosgene in THF, in the presence of one equivalent of pyridine (80% yield)[1-2].

Precautions

It may be stored in a desiccator over P2O5 at room temperature for many months without apparent decomposition.

References

1. Beyerman, H. C.; Van Den Brink, W. M. RTC 1961, 80, 1372.
2. Gais, H.-J. AG(E) 1977, 16, 244.