Chemical Properties
1,1'-Carbonyl-di(1,2,4-triazole) is beige powder
Uses
1,1'-Carbonyl-di(1,2,4-triazole) is used in epoxidation reactions in organic synthesis. It is useful in preparing acyl triazolides from carboxylic acids. 1'-Carbonyl-di(1,2,4-triazole) is a reagent for peptide synthesis; preparation of thiol or selenol esters.
Uses
N,N''-Carbonyl-di-(1,2,4-triazole) is used in preparation of the bridged cycloformylpyridine derivative and their medical applications.
reaction suitability
reaction type: Carbonylations
Synthesis
1,1'-Carbonyl-di(1,2,4-triazole) is preparate from triazole and phosgene in THF, in the presence of one equivalent of pyridine (80% yield)[1-2].
Precautions
It may be stored in a desiccator over P2O5 at room temperature for many months without apparent decomposition.
References
1. Beyerman, H. C.; Van Den Brink, W. M. RTC 1961, 80, 1372.
2. Gais, H.-J. AG(E) 1977, 16, 244.
