Description
5-OxoETE methyl ester is an esterified form of the polyunsaturated keto acid 5-oxoETE . 5-OxoETE methyl ester is an agonist of oxoeicosanoid receptor 1 (OXER1; EC
50 = 1.54 μM for β-arrestin recruitment) that has a higher maximal response than 5-oxoETE in a β-arrestin assay.
1
References
1. Stepniewski, T.M., Torrens-Fontanals, M., Rodríguez-Espigares, I., et al.
Synthesis, molecular modelling studies and biological evaluation of new oxoeicosanoid receptor 1 agonists Bioorg. Med. Chem. 26(12),3580-3587(2018).
