5-OxoETE methyl ester is an esterified form of the polyunsaturated keto acid 5-oxoETE . 5-OxoETE methyl ester is an agonist of oxoeicosanoid receptor 1 (OXER1; EC50 = 1.54 μM for β-arrestin recruitment) that has a higher maximal response than 5-oxoETE in a β-arrestin assay.1
Uses
5-OxoETE methyl ester is the agonist for oxoeicosanoid receptor 1 (OXER1). 5-OxoETE methyl ester binds to OXER1, and activates downstream signaling pathways β-arrestin recruitment with an EC50 of 1.54 μM[1].
storage
Store at -20°C
References
1. Stepniewski, T.M., Torrens-Fontanals, M., Rodríguez-Espigares, I., et al. Synthesis, molecular modelling studies and biological evaluation of new oxoeicosanoid receptor 1 agonists Bioorg. Med. Chem. 26(12),3580-3587(2018).
