PENICILLIN-STREPTOMYCIN

Uses

Penicillin-Streptomycin has been used for the prevention and elimination of bacterial contaminants in cell culture.

General Description

Penicillin (Penicillin G) inhibits bacterial growth by inhibiting peptidoglycan synthesis. Streptomycin belongs to the family of aminoglycoside antibiotics and inhibits bacterial growth by inhibiting protein synthesis.

Biological Activity

Penicillins can prevent the synthesis of bacterial cell wall. This antibiotic can be used in the treatment of skin and urinary tract infections, upper and lower respiratory infections, and endocarditis. Streptomycin can block Mycobacterium tuberculosis in vitro. Streptomycin inhibits prokaryote protein synthesis by preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding.