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LITHOCHOLIC ACID

LITHOCHOLIC ACID Structure
LITHOCHOLIC ACID
  • CAS No.434-13-9
  • Chemical Name:LITHOCHOLIC ACID
  • CBNumber:CB2342229
  • Molecular Formula:C24H40O3
  • Formula Weight:376.57
  • MOL File:434-13-9.mol
  • MSDS File:SDS
LITHOCHOLIC ACID Property
  • Melting point 183-188 °C (lit.)
  • alpha D20 +33.7° (c = 1.5 in abs ethanol); D19 +23.3° (Wieland); D20 +32.1° (Fischer)
  • Boiling point 445.09°C (rough estimate)
  • Density 1.0454 (rough estimate)
  • refractive index 35.5 ° (C=1, EtOH)
  • Flash point 9℃
  • storage temp. room temp
  • form Powder
  • pka 4.76±0.10(Predicted)
  • color White to off-white
  • Water Solubility 18.83ug/L(25 ºC)
  • Merck 5545
  • BRN 3217757
  • InChIKey SMEROWZSTRWXGI-HVATVPOCSA-N
  • CAS DataBase Reference 434-13-9(CAS DataBase Reference)
  • FDA UNII 5QU0I8393U
  • EPA Substance Registry System Lithocholic acid (434-13-9)
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H225-H301+H311+H331-H370
  • Precautionary statements P210-P260-P280-P301+P310+P330-P308+P311-P403+P233
LITHOCHOLIC ACID Price More Price(26)
  • Brand: Sigma-Aldrich
  • Product number: L6250
  • Product name : Lithocholic acid
  • Purity: ≥95%
  • Packaging: 10g
  • Price: $68.3
  • Updated: 2022/05/15
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 20253
  • Product name : Lithocholic Acid
  • Purity: ≥95%
  • Packaging: 5g
  • Price: $28
  • Updated: 2022/04/27
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 20253
  • Product name : Lithocholic Acid
  • Purity: ≥95%
  • Packaging: 10g
  • Price: $48
  • Updated: 2022/04/27
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: L6250
  • Product name : Lithocholic acid
  • Purity: ≥95%
  • Packaging: 25g
  • Price: $234
  • Updated: 2022/05/15
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: L0720800
  • Product name : Lithocholic acid
  • Purity: European Pharmacopoeia (EP) Reference Standard
  • Packaging: l0720800
  • Price: $202
  • Updated: 2022/05/15
  • Buy: Buy

LITHOCHOLIC ACID Chemical Properties,Usage,Production

  • Chemical Properties white to off-white powder
  • Uses
    Lithocholic acid has been used in a study to assess cholestasis and its action on several organs and tissues in rats. It has also been used in a study to investigate the regulation of hepatic phospholipid and bile acid homeostasis through SMAD3 activation by TGFβ.
  • Uses Cholagogue;Anticholelithogenic
  • Uses LD50(mouse) 3900 mg/kg po
  • Uses A cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones.
  • Definition ChEBI: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
  • General Description Hexagonal leaflets (from alcohols) or prisms (from acetic acid) or white powder.
  • Air & Water Reactions Insoluble in water.
  • Health Hazard ACUTE/CHRONIC HAZARDS: When heated to decomposition LITHOCHOLIC ACID emits acrid smoke and fumes.
  • Fire Hazard Flash point data for LITHOCHOLIC ACID are not available. LITHOCHOLIC ACID is probably combustible.
  • Purification Methods Lithocholic acid can be purified by conversion to the rather insoluble Na or K salt by addition of the equivalent amount of aqueous NaOH or KOH, filtering off the alkali salt, washing it with ice cold H2O, dissolving it in the least volume of boiling H2O, acidifying with the dilute HCl (slight excess), filtering off the acid, washing with cold H2O and drying it thoroughly in a vacuum. Recrystallise it from Me2CO, EtOH or acetic acid. The methyl ester crystallises from MeOH, with 0.5 mol of MeOH, and has m 92-93o, [] D 25 +34o (MeOH). It has also been purified by recrystallisation from pet ether (b 40-60o) and, after chromatography on Al2O3 in pet ether, gave a labile form m 92-93o which is transformed to the stable form m 125-126o after standing for 2days in a vacuum desiccator. [Hoelm & Mason J Am Chem Soc 62 569 1940, Sarel & Yanuka J Org Chem 24 2018 1959, Beilstein 10 IV 785.]
LITHOCHOLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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LITHOCHOLIC ACID Spectrum
434-13-9, LITHOCHOLIC ACIDRelated Search:
  • 17-beta-(1-Methyl-3-carboxypropyl)ethiocholan-3-alpha-ol
  • 17beta-(1-methyl-3-carboxypropyl)etiocholan-3alpha-ol
  • BETA-CHOLANIC ACID-3-ALPHA-OL
  • HYDROYCHOLANIC ACID
  • 3-HYDROXYCHOLANIC ACID
  • 3ALPHA-HYDROXYCHOLANIC ACID
  • 3ALPHA-HYDROXY-5BETA-CHOLANIC ACID
  • 3ALPHA-HYDROXY-5BETA-CHOLAN-24-OIC ACID
  • 5BETA-CHOLAN-24-OIC ACID-3A-OL
  • 5BETA-CHOLAN-24-OIC ACID-3ALPHA-OL
  • 5BETA-CHOLANIC ACID-3ALPHA-OL
  • LITHOCHOLIC ACID
  • Ursodeoxycholic Acid Impurity 3(Ursodeoxycholic Acid EP Impurity C)
  • Lithocolic acid
  • NCI-C03861
  • 3α-Hydroxy-5β-cholan-24-oic acid
  • 3α-Hydroxy-5β-cholanic acid
  • 5β-Cholan-24-oic acid-3α-ol
  • Lithocholic Acide
  • Lithocholic acid,3α-Hydroxy-5β-cholan-24-oic acid, 3α-Hydroxy-5β-cholanic acid, 5β-Cholan-24-oic acid-3α-ol
  • 17β-(1-Methyl-3-car-boxypropyl) etiocholan-3α-ol
  • (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,]
  • LITHOCHOLIC ACID(RG)
  • 3α-Hydroxy-5β-cholan-24-oic acid, 3α-Hydroxy-5β-cholanic acid, 5β-Cholan-24-oic acid-3α-ol
  • 3β-Hydroxyallocholanic acid
  • NCI-CO-3861
  • Lithocholic acid,98%
  • Lithocholic acid3alpha-Hydroxycholanic acid
  • Lithocholic acid, 98% 5GR
  • (3α,5β)-3-Hydroxycholan-24-oic Acid
  • 3α-Hydroxy-5β-cholan-24-oate
  • 3α-Hydroxy-5β-cholanoic Acid
  • 5beta-Cholanic Acid-3alpha-ol 3alpha-Hydroxy-5beta-cholanic Acid
  • 3-alpha-hydroxy-5-beta-cholan-24-oicaci
  • 3alpha-hydroxy-5beta-cholan-24-oicaci
  • 3-alpha-hydroxy-5-beta-cholanicaci
  • 3alpha-Hydroxy-5beta-cholanoic acid
  • 3alpha-hydroxy-5beta-cholanoicacid
  • 3-hydroxy-,(3-alpha,5-beta)-cholan-24-oicaci
  • 3-hydroxy-,(3alpha,5beta)-cholan-24-oicaci
  • 3-Hydroxycholan-24-oic acid
  • 3-hydroxycholan-24-oicacid
  • 5beta-Cholan-24-oic acid, 3alpha-hydroxy-
  • 5-beta-Cholanic acid, 3-alpha-hydroxy-
  • Cholan-24-oic acid, 3-hydroxy-, (3alpha,5beta)-
  • Lithocholate
  • Cholan-24-oic acid, 3-hydroxy-, (3α,5β)-
  • Lithocholic aCld
  • LITHOCHOLIC ACID >=95%
  • Ursodeoxycholic Acid EP Impurity C
  • Stone cholic acid
  • (R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
  • Chenodeoxycholic Acid Impurity 3
  • Lithocholic acid CRS
  • LithocholicAcid&gt
  • LITHOCHOLIC ACID USP/EP/BP
  • Chenodeoxycholic acid EP Impurity C
  • ALPHA-HYDROXY-5BETA-CHOLANIC ACID