N-(Azido-PEG2)-N-Boc-PEG3-acid

Description

N-(Azido-PEG2)-N-Boc-PEG3-acid is a multifunction PEG linker. The azide group enables PEGylation via Click Chemistry. Boc can be deprotected under acidic conditions. The terminal carboxylic acid can react with primary amino groups in the presence of activators (e.g. EDC, or HATU).

Uses

N-(Azido-PEG2)-N-Boc-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG2)-N-Boc-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005