Azido-PEG1-CH2CO2-NHS

Description

Azido-PEG1-CH2CO2-NHS is a PEG linker containing azide and NHS ester moieties. The hydrophilic PEG spacer increases the water solubility of compounds in aqueous media. The azide group can react with alkynes, BCN and DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Uses

Azido-PEG1-CH2CO2-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-CH2CO2-NHS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005