2-Bromo-4-thiazolecarboxylic acid

Uses

Thiazole compounds are important pharmaceutical and chemical intermediates, characterized by low toxicity, excellent biological activities (such as acaricidal, bactericidal, and inhibitory effects on insect pheromone synthesis), and diverse structural variations. Thiazole 2-bromo-4-thiazolium carboxylic acid is a key intermediate in the synthesis of thiabendazole.

Chemical Properties

Pale yellow crystals

Synthesis

Ethyl 2-aminothiazole-4-carboxylate was synthesized solvent-free from thiourea and ethyl bromopyruvate as reagent, then ethyl 2-bromothiazole-4-carboxylate was obtained by high-temperature diazotization with DM SO and sodium nitrite, and finally the target 2-bromo-4-thiazolecarboxylate was obtained by saponification with potassium carbonate-methanol solution

.