Synthesis
General procedure for the synthesis of potassium 2-methoxy-2-oxoacetate from dimethyl oxalate: 1.2 g of dimethyl oxalate and 0.98 g of potassium acetate were dissolved in a mixed solvent of 10 mL of methanol and 10 mL of water. The reaction mixture was stirred at 80 °C for 3 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. A white solid product was obtained in quantitative yield.
References
[1] Patent: WO2005/53609, 2005, A2. Location in patent: Page/Page column 25-26
[2] Patent: CN105439883, 2016, A. Location in patent: Paragraph 0051
[3] Chemical and Pharmaceutical Bulletin, 1998, vol. 46, # 3, p. 514 - 517
[4] Journal of the American Chemical Society,
