10304-09-3

General procedure for the synthesis of potassium 2-methoxy-2-oxoacetate from dimethyl oxalate: 1.2 g of dimethyl oxalate and 0.98 g of potassium acetate were dissolved in a mixed solvent of 10 mL of methanol and 10 mL of water. The reaction mixture was stirred at 80 °C for 3 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. A white solid product was obtained in quantitative yield.

[1] Patent: WO2005/53609, 2005, A2. Location in patent: Page/Page column 25-26
[2] Patent: WO2005/53609, 2005, A2. Location in patent: Page/Page column 25-26
[3] Patent: CN105439883, 2016, A. Location in patent: Paragraph 0051
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[5] Journal of the American Chemical Society,