Description
BML-111 (78606-80-1) novel truncated analog of lipoxin A4 which retains anti-inflammatory activity.1 Inhibits LTB4-induced leukocyte chemotaxis, IC50=5 nM).1 Attenuates hemorrhagic shock-induced acute lung injury in a rat model.2 Displays hepatoprotective effects in acetaminophen-induced liver injury in mice.3 Limits inflammatory damage in the cerebral cortex and helps maintain blood brain barrier integrity in a rat model of ischemic stroke.4 Attenuates renal ischemia/reperfusion injury via activation of p38 MAPK/PPARa/HO-1 pathway.5
References
[1] TAK H. LEE. Inhibition of leukotriene B4-induced neutrophil migration by lipoxin A4: Structure-function relationships[J]. Biochemical and biophysical research communications, 1991, 180 3: Pages 1416-1421. DOI:
10.1016/s0006-291x(05)81354-3[2] MD H B L, PHD, PHD You S M, et al. BML-111 attenuates hemorrhagic shock-induced acute lung injury through inhibiting activation of mitogen-activated protein kinase pathway in rats[J]. Journal of Surgical Research, 2013, 183 2: Pages 710-719. DOI:
10.1016/j.jss.2013.03.007[3] DINA S EL-AGAMY Nareman M G Mirhan N Makled. Protective effects of BML-111 against acetaminophen-induced acute liver injury in mice.[J]. Journal of physiology and biochemistry, 2014, 70 1: 141-149. DOI:
10.1007/s13105-013-0288-x[4] KIMBERLY E. HAWKINS. Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke[J]. Journal of Neurochemistry, 2013, 129 1: 130-142. DOI:
10.1111/jnc.12607[5] SHENG-HUA WU. BML-111 Attenuates Renal Ischemia/Reperfusion Injury Via Peroxisome Proliferator-Activated Receptor-α-Regulated Heme Oxygenase-1[J]. Inflammation, 2015, 39 1: 611-624. DOI:
10.1007/s10753-015-0286-y
