BM-1074 (i.v., 15 mg/kg, daily, 5 days a week for 2 weeks) exhibits the maximum tolerated dose (MTD) (15 mg/kg) and strong antitumor activity in H146 tumor xenograft mice, as well as shows no significant weight loss (<5%) or other signs of toxicity[1].
BM-1074 (i.v., 15 mg/kg, single) induces strong apoptosis in H146 tumor tissues[1].
| Animal Model: | SCID mice (injected with 5 x 106 H146 cancer cells with Matrigel, subcutaneously)[1] |
| Dosage: | 15 mg/kg |
| Administration: | i.v., 15 mg/kg, daily, 5 days a week for 2 weeks |
| Result: | Showed good toleration and did not cause significant weight loss or other signs of toxicity, also induced completely and persistent tumor regression in the H146 xenograft model. |
| Animal Model: | SCID mice (injected with 5 x 106 H146 cancer cells with Matrigel, subcutaneously)[1] |
| Dosage: | 15 mg/kg |
| Administration: | i.v., 15 mg/kg, single dosage |
| Result: | Induced robust cleavage of PARP and caspase-3 at both 3 and 6-hr time-points in H146 tumor tissues. |
