Description
N-
Acylated ethanolamines (NAE) are naturally-
occurring lipids that have diverse bioactivities. The different types of NAE can be derived from glycerophospho-
linked precursors by the activity of glycerophosphodiesterase 1 (GDE1). Glycerophospho-
N-
arachidonoyl ethanolamine is the precursor of arachidonoyl ethanolamide (AEA), also known as anandamide. AEA is an endogenous cannabinoid neurotransmitter that binds to both central cannabinoid (CB
1) and peripheral cannabinoid (CB
2) receptors. It inhibits the specific binding of [
3H]-
HU-
243 to synaptosomal membranes with a K
i value of 52 nM, compared to 46 nM for Δ
9-
THC.
Uses
Glycerophospho-N-arachidonoyl ethanolamine is the precursor of arachidonoyl ethanolamide (AEA), also known as anandamide.
Definition
ChEBI: Glycerophospho-N-Arachidonoyl Ethanolamine is a glycerophosphoethanolamine.
References
[1] GABRIEL M SIMON B F C. Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain.[J]. The Journal of Biological Chemistry, 2008, 283 14: 9341-9349. DOI:
10.1074/jbc.m707807200[2] C C FELDER. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1993, 90 16: 7656-7660. DOI:
10.1073/pnas.90.16.7656[3] WILLIAM A. DEVANE. Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor[J]. Science, 1992, 258 5090. DOI:
10.1126/science.1470919
