201738-25-2

N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities. The different types of NAE can be derived from glycerophospho-linked precursors by the activity of glycerophosphodiesterase 1 (GDE1). Glycerophospho-N-arachidonoyl ethanolamine is the precursor of arachidonoyl ethanolamide (AEA), also known as anandamide. AEA is an endogenous cannabinoid neurotransmitter that binds to both central cannabinoid (CB₁) and peripheral cannabinoid (CB₂) receptors. It inhibits the specific binding of [³H]-HU-243 to synaptosomal membranes with a K_i value of 52 nM, compared to 46 nM for Δ⁹-THC.

Glycerophospho-N-arachidonoyl ethanolamine is the precursor of arachidonoyl ethanolamide (AEA), also known as anandamide.

ChEBI: Glycerophospho-N-Arachidonoyl Ethanolamine is a glycerophosphoethanolamine.

Store at -20°C

[1] GABRIEL M SIMON B F C. Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain.[J]. The Journal of Biological Chemistry, 2008, 283 14: 9341-9349. DOI: 10.1074/jbc.m707807200
[2] C C FELDER. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1993, 90 16: 7656-7660. DOI: 10.1073/pnas.90.16.7656
[3] WILLIAM A. DEVANE. Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor[J]. Science, 1992, 258 5090. DOI: 10.1126/science.1470919