201738-25-2

N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities. The different types of NAE can be derived from glycerophospho-linked precursors by the activity of glycerophosphodiesterase 1 (GDE1). Glycerophospho-N-arachidonoyl ethanolamine is the precursor of arachidonoyl ethanolamide (AEA), also known as anandamide. AEA is an endogenous cannabinoid neurotransmitter that binds to both central cannabinoid (CB₁) and peripheral cannabinoid (CB₂) receptors. It inhibits the specific binding of [³H]-HU-243 to synaptosomal membranes with a K_i value of 52 nM, compared to 46 nM for Δ⁹-THC.

Glycerophospho-N-arachidonoyl ethanolamine is the precursor of arachidonoyl ethanolamide (AEA), also known as anandamide.

ChEBI: Glycerophospho-N-Arachidonoyl Ethanolamine is a glycerophosphoethanolamine.

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