U 90042

Uses

U 90042 is a sedative and hypnotic compound that interacts differentially with the GABAA receptor subtypes.

Biological Activity

GABA A receptor ligand that binds with comparable affinities to three receptor subtypes: α 1 β 2 γ 2 , α 3 β 2 γ 2 and α 6 β 2 γ 2 (K i values are 7.8, 9.5 and 11.0 nM respectively). Potentiates GABA-induced chloride currents in α 6 β 2 γ 2 receptors. Sedative/hypnotic compound.