Synthesis
Under the protection of high-purity nitrogen, 0.05 mmol of heteronuclear ruthenium-palladium bicyclic metal compound 1, 1 mmol of o-iodoacetophenone, 2.5 mmol of benzyl alcohol, 2 mmol of potassium hydroxide, and 3 ml of dioxin were added to a 10 ml Schlek reaction tube, and the reaction tube was displaced with nitrogen for three times, and then the reaction was refluxed for 30 hours by heating with an oil bath under magnetic stirring to 110C. The reaction was carried out with the addition of 3 ml of water. Remove the oil bath, the water bath was reduced to room temperature; to the reaction solution added 3 ml of water, extracted with 5 ml of dichloromethane three times, the organic phase was combined and dried with anhydrous MgSO4 for 30 minutes, filtration, the filtrate was concentrated with a rotary evaporator, and the residue was used as a spreading agent with a mixture of dichloromethane/petroleum ether, separated by silica gel thin-layer chromatography, to obtain the pure product of 3-phenyl-1-indanone.
