Uses
Diethyl Methylsulfonylmethylphosphonate is used for the preparation of synthetically versatile vinyl sulfones from aldehydes and ketones.
Preparation
Preparative Methods: conveniently prepared by oxidation of Diethyl Methylthiomethylphosphonate (eq 1).
Both inorganic oxidants (e.g. Potassium Permanganate in water or Hydrogen Peroxide/Selenium(IV)
Oxide) and organic oxidants (e.g. Peracetic Acid in ether or m-Chloroperbenzoic Acid in CH2Cl2
) have
been used to accomplish this transformation.
storage
Diethyl methylsulfonylmethylphosphonate is reasonably stable for
storage. Reactions involving this reagent are best conducted under anhydrous conditions, under nitrogen, in a
well ventilated fume hood.
