Description
Dnp-P-Cha-Abu-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-9. It is cleaved by MMP-1 and MMP-9 to release N-methylanthranilic acid (Nma), which is unquenched and its fluorescence can be used to quantify MMP activity.
Uses
MMP-1 Substrate is a matrix metalloproteinase-1 (MMP-1) selective substrate that can be used for the fluorometric determination of MMP-1 enzymatic activity[1].
References
[1] Kumar JD, et al. Gastrin stimulates MMP-1 expression in gastric epithelial cells: putative role in gastric epithelial cell migration. Am J Physiol Gastrointest Liver Physiol. 2015 Jul 15;309(2):G78-86. DOI:
10.1152/ajpgi.00084.2015
Sequene
Dnp-Pro-Cha-Abu-Cys(Me)-His-Ala-Lys(Nma)-NH2