2-(Benzyloxy)-ethylamine

Uses

2-(Benzyloxy)-1-ethanamine (2-(Benzyloxy)ethylamine) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis Reference(s)

Tetrahedron Letters, 36, p. 3465, 1995 DOI: 10.1016/0040-4039(95)00527-J

Synthesis

GENERAL METHOD: Compound (CAS: 87107-79-7) (3 mmol) was dissolved in ethanol (30 mL) at 50 °C, followed by slow addition of 85% hydrazine hydrate (0.19 mL, 3.3 mmol). The reaction temperature was maintained at 50 °C and the reaction mixture was stirred continuously for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solids were separated by filtration. The filtrate was concentrated under reduced pressure to give the crude product 2-(benzyloxy)ethylamine in 90% yield.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 14, p. 2782 - 2787
[2] Patent: WO2012/64680, 2012, A1. Location in patent: Page/Page column 142
[3] Patent: WO2012/62157, 2012, A1. Location in patent: Page/Page column 142; 143
[4] Patent: US2011/178077, 2011, A1. Location in patent: Page/Page column 14