Description
Picaridin is an insect repellent. It inhibits
A. aegypti odorant receptor 2 (AaOR2) or AaOR8 in the presence of their odorant activators, indole and octenol, respectively, expressed in
Xenopus oocytes (IC
50s = 1,452 and 1,911 μM, respectively). Picaridin reduces the number of entries into a food chamber by female
D. melanogaster in an olfactory-based choice assay. It acts synergistically with the non-pyrethroid insecticide pyrimiphos methyl to increase mortality of
A. gambiae and reduce blood feeding when used at a concentration of 10 g/m
2 on nets surrounding guinea pig cages. Formulations containing picaridin have been used as insect repellents against flies, mosquitoes, chiggers, ticks, and fleas.
Chemical Properties
Colorless Liquid
Uses
Acts on certain olfactory receptor cell types to reduce the activating or attracting effect of odor sources.Insect repellent.
Definition
ChEBI: Butan-2-yl 2-(2-hydroxyethyl)piperidine-1-carboxylate is a carboxylic acid and a member of piperidines.
Production Methods
Commercial production of icaridin involves a highly optimised chemical synthesis process developed to meet global demand for safe and effective insect repellents. The active ingredient is a piperidine derivative, and its synthesis typically starts with cyclohexane derivatives, which undergo a series of reactions including chlorination, etherification, and nitrile formation to build the final molecular structure.
Hazard
A reproductive hazard.
Mechanism of action
Topically applied, repellent. Odorant receptor. It has been proposed that icaridin may bind to odorant binding protein 1 (AgamOBP1).
References
[1] JONATHAN D BOHBOT Joseph C D. Insect repellents: modulators of mosquito odorant receptor activity.[J]. PLoS ONE, 2010: e12138. DOI:
10.1371/journal.pone.0012138[2] ZAINULABEUDDIN SYED. Generic insect repellent detector from the fruit fly Drosophila melanogaster.[J]. PLoS ONE, 2011: e17705. DOI:
10.1371/journal.pone.0017705[3] CéDRIC PENNETIER. Synergy between repellents and non-pyrethroid insecticides strongly extends the efficacy of treated nets against Anopheles gambiae.[J]. ACS Applied Bio Materials, 2007: 38. DOI:
10.1186/1475-2875-6-38
Pesticide Type
Insecticide; Repellent; Veterinary substance
