ChemicalBook CAS DataBase List 8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE

8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE

Product Name8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE
CAS691868-88-9
CBNumberCB2134747
MFC14H5F6N5O
MW373.21
MDL NumberMFCD03102493
MOL FileMol file

Chemical Properties

storage temp.	Store at 2-8°C
solubility	≤0.1mg/ml in DMSO;0.5mg/ml in dimethyl formamide
form	crystalline solid
color	Off-white to yellow

Safety

Symbol(GHS)

Signal word

Danger

Hazard statements

H301

Precautionary statements

P264-P270-P301+P310-P321-P330-P405-P501

NFPA 704:

	0
2		0

8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE Price

Product number	Packaging	Price	Product description	Buy
Cayman Chemical 20449	1mg	$32	RO8191 ≥98%	Buy
Cayman Chemical 20449	5mg	$109	RO8191 ≥98%	Buy
Cayman Chemical 20449	10mg	$153	RO8191 ≥98%	Buy
Cayman Chemical 20449	25mg	$343	RO8191 ≥98%	Buy
ApexBio Technology C4533	25mg	$435	RO8191	Buy

8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE Chemical Properties,Usage,Production

Biological Activity

ec50: 0.2 μm for anti-hcv activityro8191 is an ifn-α receptor 2 agonist.most acute hepatitis c virus (hcv) infections become chronic and some progress to liver cirrhosis or hepatocellular carcinoma, with thes tandard therapy involving an interferon (ifn)-α-based regimen.

in vitro

previous study found that ro8191had remarkable anti-hcv activity. more importantly, ro8191 exerted its antiviral activity by directly interacting with the type i ifn receptor to drive ifn-stimulated genes (isg) expression, which then induced the antiviral response of innate immune system. previous researchers conducted a systematic structure activity relationship (sar) study on ro8191, and although more than 100 analogues were synthesized, none of the analogues displayed improved anti-hcv activity, suggesting that ro8191 displayed a relative narrow window of sar [1].

in vivo

a previous study evaluated the effects of ro8191 on ifn signaling in mice. results showd that the antiviral genes were significantly induced in the livers of mice treated with ro8191. in addition, genes that had previously been reported to be induced by ifn-b in mouse liver were also induced in the livers of ro8191-treated mice. this study also measured inflammatory cytokine and chemokine expressions, and ro8191 did not significantly induce the expression of these genes. to evaluate the in-vivo anti-hcv activity of ro8191, ro8191 was orally administered to hcv-infected humanized liver mice, and the results showed that ro8191 was able to reduce hcv titer in vivo [2].

target

storage

Store at -20°C

References

[1] wang h, wang s, cheng l, chen l, wang y, qing j, huang s, wang y, lei x, wu y, ma z, zhang l, tang y. discovery of imidazo[1,2-α][1,8]naphthyridine derivatives as potential hcv entry inhibitor. acs med chem lett. 2015 jul 27;6(9):977-81.
[2] konishi h et al. an orally available, small-molecule interferon inhibits viral replication. sci rep. 2012;2:259.

Preparation Products And Raw materials

8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE Suppliers

JAK1

IFNAR2

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Suzhou ARTK Medchem Co., Ltd.	+86-512-68323658 +86-18168183658	sales1@artkmedchem.com	China	39004	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973130 4009686088	3193328036@qq.com	China	29785	68
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 18892239720	psaitong@jm-bio.com	China	12306	58
MQ (shanghai) Pharmaceuticals Co., Ltd.	13761635123	1014988033@qq.com	China	4997	55
Jiangsu aikang biomedical research and development co., LTD	025-66110311 13155353615	qzhang@aikonchem.com	China	15527	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
Shanghai Kaiwei Chemical Technology Co., Ltd.	021-58461859 15821823057	service@aiviche.com	China	49312	58
Guangzhou Younan Technology Co., Ltd	020-82000279 18988968278	sales@ubiochem.com	China	4297	58

View Lastest Price from 8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE manufacturers

Send Inquriy