Uses
Triosephosphate isomerase has been used in a study to assess molecular characterizations of
Cryptosporidium,
Giardia, and
Enterocytozoon. Triosephosphate isomerase has also been used in a study to investigate apoptosis of
hepatocellular carcinoma cell lines.
General Description
Triosephosphate isomerase (TPI) gene is located on human chromosome 12p13. It is expressed in all tissues. This homodimer of two 27 kDa subunits is highly stable and is made up of 248 amino acids. TPI is catalytically active in its dimeric state.
Biochem/physiol Actions
Triosephosphate isomerase(TPI) is responsible for the catalysis of the triose phosphate isomers, dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. TPI deficiency is associated with glycolytic enzymopathy. Lack of TPI is also associated with chronic hemolytic anemia, enhanced exposure to bacterial infections, cardiomyopathy and neuromuscular disease.
