Uses
Mebendazole-d8 is the deuterium labeled Mebendazole. Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations; has been found as a hedgehog inhibitor[1][2].
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:
10.1177/1060028018797110[2] HOSSEIN ALEYASIN. Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin.[J]. Antioxidants & redox signaling, 2015, 22 2: 121-134. DOI:
10.1089/ars.2013.5595[3] U M MORGAN R C T J A Reynoldson. Activities of several benzimidazoles and tubulin inhibitors against Giardia spp. in vitro.[J]. Antimicrobial Agents and Chemotherapy, 1993, 37 2: 328-331. DOI:
10.1128/aac.37.2.328[4] NICOLE DOUDICAN. Mebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells.[J]. Molecular Cancer Research, 2008, 6 8: 1308-1315. DOI:
10.1158/1541-7786.mcr-07-2159[5] TAPAS MUKHOPADHYAY. Mebendazole elicits a potent antitumor effect on human cancer cell lines both in vitro and in vivo.[J]. Clinical Cancer Research, 2002, 8 9: 2963-2969.
[6] M L COLGLAZIER K C K F D Enzie. Critical anthelmintic trials in ponies with four benzimidazoles: mebendazole, cambendazole, fenbendazole, and albendazole.[J]. Journal of Parasitology, 1977, 63 4: 724-727.
