PARP1-IN-5 (dihydrochloride)
- Product NamePARP1-IN-5 (dihydrochloride)
- CAS2823308-89-8
- CBNumberCB19923772
- MFC25H25ClN2O5S
- MW500.99
- EINECS-0
- MOL File2823308-89-8.mol
- MSDS FileSDS
Chemical Properties
| form | Solid |
| color | Light yellow to green yellow |
PARP1-IN-5 (dihydrochloride) Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| ChemScene CS-0200348 | 5mg | $271 | PARP1-IN-5 (dihydrochloride) 97.56% |
Buy |
| ChemScene CS-0200348 | 10mg | $412 | PARP1-IN-5 (dihydrochloride) 97.56% |
Buy |
| ChemScene CS-0200348 | 25mg | $812 | PARP1-IN-5 (dihydrochloride) 97.56% |
Buy |
| ChemScene CS-0200348 | 50mg | $1137 | PARP1-IN-5 (dihydrochloride) 97.56% |
Buy |
| ChemScene CS-0200348 | 100mg | $1571 | PARP1-IN-5 (dihydrochloride) 97.56% |
Buy |
PARP1-IN-5 (dihydrochloride) Chemical Properties,Usage,Production
Uses
PARP1-IN-5 dihydrochloride is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer[1].in vivo
PARP1-IN-5 dihydrochloride (1000 mg/kg; p.o.) shows that there is no significant difference in the body weight and blood routine[1].
PARP1-IN-5 dihydrochloride (25 and 50 mg/kg; p.o.; 12 days) significantly enhances the inhibitory effect of carboplatin on A549 cells at 50 mg/kg[1].
PARP1-IN-5 dihydrochloride (50 mg/kg; p.o.) positively correlates with the expression of PARP-1[1].
PARP1-IN-5 dihydrochloride can upregulate the expression of γ-H2AX and decrease the expression of PAR[1].
| Animal Model: | Mice[1] |
| Dosage: | 1000 mg/kg |
| Administration: | P.o. |
| Result: | There was no significant difference in the body weight and blood routine. |
| Animal Model: | Mice[1] |
| Dosage: | 25 and 50 mg/kg |
| Administration: | P.o.; 12 days |
| Result: | Significantly enhanced the inhibitory effect of CBP on A549 cells at 50 mg/kg. |
| Animal Model: | Male SpragueDawley (SD) rats[1] |
| Dosage: | 50 mg/kg (Pharmacokinetic Analysis) |
| Administration: | P.o. |
| Result: | Positively correlated with the expression of PARP-1. |
IC 50
PARP-1: 14.7 nM (IC50); PARP-2: 0.9 μM (IC50)References
[1] Long H, et al. Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer. J Med Chem. 2021;64(16):12089-12108. DOI:10.1021/acs.jmedchem.1c00735Preparation Products And Raw materials
PARP1-IN-5 (dihydrochloride) Suppliers
Global(16)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 1-631-485-4226; 16314854226 |
info@bocsci.com | United States | 9920 | 65 | |
| 021-52996696，15000506266 15000506266 |
China | 4865 | 55 | ||
| 13816613772 | huahero21@sina.com | China | 2996 | 55 | |
| +86-02787215551 19945035818 |
2936752263@qq.com | China | 7984 | 58 | |
| 15865264761 | 486064515@qq.com | China | 4982 | 58 | |
| 027-59101668 19945030958 |
2223443625@qq.com | China | 7998 | 58 | |
| 400-1647117 13681763483 |
product02@bidepharm.com | China | 59929 | 58 | |
| 4008200310 15002144251 |
marketing@tsbiochem.com | China | 24951 | 58 | |
| 0371-53370800 18037197114 |
3807961510@qq.com | China | 9957 | 58 | |
| 0513-66337626 18051384581 |
sales@chemhifuture.com | China | 5984 | 58 |
PARP1-IN-5 (dihydrochloride) Spectrum
2823308-89-8, PARP1-IN-5 (dihydrochloride)Related Search
PROMPT×
PROMPT
The WhatsApp is temporarily not supported in mainland China
The WhatsApp is temporarily not supported in mainland China
Cancel
Determine