1,3-bis[3-(dimethylamino)propyl]urea

Synthesis

A mixture of N,N-dimethyl-1,3-diaminopropane (51.09 g, 0.5 mol) and urea (15.01 g, 0.25 mol) was added to a round bottom flask. The reaction system was heated to 125 °C and kept under reflux with stirring for 8 hours. During the reaction, high purity nitrogen was continuously passed to bring out the generated ammonia and trap it by 30 wt% sulfuric acid solution. Upon completion of the reaction, a clarified colorless liquid product of 1,3-bis[3-(dimethylamino)propyl]urea (58.52 g, yield: 88.65%) was obtained.

References

[1] Journal of the Electrochemical Society, 2014, vol. 161, # 12, p. D651 - D656
[2] Journal of Organometallic Chemistry, 2005, vol. 690, # 11, p. 2757 - 2760