Trastuzumab Deruxtecan

Product NameTrastuzumab Deruxtecan
CAS1826843-81-5
CBNumberCB18081028
MW0
MOL FileMol file

Chemical Properties

storage temp.	Solution, -20°C, 2 years
solubility	Soluble in acetonitrile
form	Solid
color	White to off-white
FDA UNII	5384HK7574
ATC code	L01XC41

Trastuzumab Deruxtecan Chemical Properties,Usage,Production

Biological Activity

Trastuzumab deruxtecan (DS-8201a) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC).

in vitro

Trastuzumab deruxtecan (1 pM-10 nM; 5 days) inhibits the growth of HER2‐positive KPL‐4 cells, with an IC ₅₀ of 109.7 pM.
Trastuzumab deruxtecan (10 nM; 5 days) shows bystander killing effects in HER2‐negative MDA‐MB‐468 cells.

in vivo

Trastuzumab deruxtecan (3 mg/kg; a single iv) shows antitumor activity against not only HER2‐positive tumors but also HER2‐negative tumors under the co‐inoculated condition.

Preparation Products And Raw materials