Description
16,16-dimethyl PGE
1 is a metabolically stable synthetic analog of PGE
1. It induces human vascular smooth muscle contractions
in vitro. It is 2, 3, and 6 times more potent than PGF
2α in contracting tracheal, bronchial, and bronchiolar smooth muscle, respectively.
1
Uses
16,16-Dimethylprostaglandin E1 (16,16-dimethyl-PGE1) is a PGE1 (HY-B0131) analog, induces bronchoconstrict and vascular smooth muscle contractions and suppresses the indomethacin induced cellular elongation[1][2][3].
Definition
ChEBI: 16,16-dimethyl-PGE1 is a prostanoid.
in vivo
16,16-Dimethylprostaglandin E1 (1 μg/kgmin for 30 min) accelerates blood pressure and heart rate recovery rate, increases catecholamine turnover, enhances levels of epinephrine and norepinephrine in plasma following acute hemorrhage in Sprague Dawley rats[1].
| Animal Model: | Sprague-Dawley rats[1] |
| Dosage: | 1 μg/kgmin |
| Administration: | 0-30 min |
| Result: | Improved blood pressure and heart rate, improved levels of epinephrine and norepinephrine im plasma. |
References
1. Karim, S.M.M., Adaikan, P.G., and Kottegoda, S.R.
Prostaglandins and human respiratory tract smooth muscle: Structure activity relationship Adv. Prostaglandin Thromboxane Res. 7,969-980(1980).
