Chemical Properties
White to yellowish crystals
Uses
Acetoacetamide is used as intermediate for different organic syntheses, mainly organic dyestuffs. Product Data Sheet
Uses
Acetoacetamide is a β-keto amide commonly used in building heterocyclic systems. It can be used in synthesizing various
N-substituted acetoacetamides, that are primary precursors for several organic dyes and pigments.
Uses
Acetoacetamide was used in a study to assess the stability of artificial sweeteners- aspartame, acesulfame-K and binary sweetener blend of aspartame x acesulfame-K during storage. Acetoacetamide was also used in analysis of multiple sweeteners and their degradation products in lassi by HPLC.
Definition
ChEBI: Acetoacetamide is a monocarboxylic acid amide of acetoacetic acid. It is functionally related to an acetoacetic acid.
General Description
Acetoacetamide is a degradation product of acesulfame-K, sweetener. Acetoacetamide undergoes alkaline hydrolysis to form salt of acetoacetic acid.
Flammability and Explosibility
Not classified
Purification Methods
Recrystallise the amide from CHCl3, or Me2CO/pet ether. It also crystallises from pyridine with 4mols of solvent. It is slightly soluble in H2O, EtOH and AcOH but is insoluble in Et2O. The phenylhydrazone has m 128o. [Kato Chem Pharm Bull Jpn 15 921 923 1967, Claisen & Meyer Chem Ber 35 583 1902, Beilstein 3 H 659, 3 I 231, 3 III 1204, 3 IV 1545.]
