Uses
Glucose-6-Phosphatase from rabbit liver has been used in glucose 6-phosphatase inhibitory assay of crude
C. anisata leaf extracts and methanolic leaf and bark extracts of
Dolichandrone atrovirens.
Definition
An enzyme produced by the kidney and liver of vertebrates. It catalyzes the conversion of glucose-6-phosphate into glucose, enabling release into the circulating blood.
General Description
Glucose-6-phosphatase is a multicomponent protein complex comprising of glucose-6-phosphate transporter (G6PT) and a catalytic unit (G6PC). Liver and kidney cells show predominant expression of glucose-6-phosphatase.
Biochem/physiol Actions
Glucose-6-Phosphatase is crucial for regulating glucose homeostasis during starvation. Deficiency of glucose-6-phosphatase is implicated in glycogen storage disease type I (GSDI).
