5-Amino-6-(D-ribitylamino)uracil (hydrochloride)

Description

5-Amino-6-(D-ribitylamino)uracil (5-A-RU) is a derivative of uracil (Item No. 26088) and a precursor to riboflavin.1,2 It reacts non-enzymatically with dihydroxy acetone, methylglyoxal, or glyoxal to activate mucosal-associated invariant T (MAIT) cells isolated from iVα19-Tg and iVα19Vβ6-DTg mice.2 5-A-RU (100 nmol/animal, i.p.), when administered in combination with methylglyoxal, activates MAIT cells in iVα19 Cα-/--Tg mice. It is also a substrate for F0 synthase, an enzyme involved in the biosynthesis of the energy metabolism cofactor F420 in archaea, bacteria, and eukaryotes.1WARNING This product is not for human or veterinary use.

References

[1] LAURE DECAMPS. Biosynthesis of F0, Precursor of the F420 Cofactor, Requires a Unique Two Radical-SAM Domain Enzyme and Tyrosine as Substrate[J]. Journal of the American Chemical Society, 2012, 134 44: 18173-18176. DOI: 10.1021/ja307762b
[2] CLAIRE SOUDAIS. In Vitro and In Vivo Analysis of the Gram-Negative Bacteria-Derived Riboflavin Precursor Derivatives Activating Mouse MAIT Cells.[J]. Journal of immunology, 2015: 4641-4649. DOI: 10.4049/jimmunol.1403224