Synthesis
General procedure for the synthesis of 1,2-diamino-3-methoxybenzene from 2-nitro-3-methoxyaniline: 5% palladium-carbon catalyst (18 mg, 20 wt%) was added to a solution of 2-nitro-3-methoxyaniline (90 mg, 0.54 mmol) in ethanol (3 mL). The reaction mixture was stirred at room temperature in a hydrogen atmosphere for 18 hours. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was subsequently evaporated to afford the target product 3-methoxy-1,2-benzenediamine (73 mg, 100% yield).
References
[1] Patent: WO2006/50506, 2006, A1. Location in patent: Page/Page column 126
[2] Bulletin of the Korean Chemical Society, 2010, vol. 31, # 11, p. 3441 - 3444
[3] Patent: EP2168959, 2010, A1. Location in patent: Page/Page column 121
[4] Patent: EP2168960, 2010, A1. Location in patent: Page/Page column 61-62
[5] Patent: US2011/301170, 2011, A1. Location in patent: Page/Page column 29
