Uses
1,1,1-Trimethylhydrazinium iodide (TMHI) may be employed for the amination of 1-X-3,5-dinitrobenzenes.
General Description
1,1,1-Trimethylhydrazinium iodide ([(CH
3)
3N-NH
2]I, TMHI) is widely employed as a vicarious nucleophilic substitution (VNS) reagent for various aromatic amination reactions. On reaction with silver salt, it affords the following salts: nitrate (([(CH
3)
3N-NH
2][NO
3]), perchlorate ([(CH
3)
3N-NH
2][ClO
4]), azide ([(CH
3)
3N-NH
2][N
3]), 5-amino-1
H-tetrazolate ([(CH
3)
3N-NH
2][H
2N-CN
4]) and sulfate ([(CH
3)
3N-NH
2]
2[SO
4].2H
2O).
