ChemicalBook CAS DataBase List Trehalose 6,6'-dimycolate

Trehalose 6,6'-dimycolate

Product NameTrehalose 6,6'-dimycolate
CAS61512-20-7
CBNumberCB1389627
MFC130H250O15.C2H6
MW0
MDL NumberMFCD18643296
MOL FileMol file
MSDS FileSDS

Chemical Properties

storage temp.	−20°C
form	Powder
color	White to off-white

Safety

WGK Germany

Trehalose 6,6'-dimycolate Price

Product number	Packaging	Price	Product description	Buy
Sigma-Aldrich T3034	1mg	$173	Trehalose 6,6′-dimycolate from Mycobacterium bovis ≥97% 6,6′-mycolate esters basis	Buy
Sigma-Aldrich T3034	2.5mg	$340	Trehalose 6,6′-dimycolate from Mycobacterium bovis ≥97% 6,6′-mycolate esters basis	Buy
Biosynth OT10667	0.05mg	$228.58	Trehalose 6,6'-dimycolate	Buy
Biosynth OT10667	0.1mg	$338.63	Trehalose 6,6'-dimycolate	Buy
Biosynth OT10667	0.25mg	$627.1	Trehalose 6,6'-dimycolate	Buy

Trehalose 6,6'-dimycolate Chemical Properties,Usage,Production

Uses

Trehalose 6,6'-dimycolate (Cord Factor) is trehalose 6,6'-dimycolate, a cell wall glycolipid of Mycobacterium tuberculosis, which can be used to simulate inflammation and granuloma induced by Mycobacterium tuberculosis (MTB) form. Trehalose 6,6′-dimycolate also protects Mycobacterium tuberculosis from macrophage-mediated killing, inhibits efficient antigen presentation, and reduces the development of protective T cell responses[1][2].

in vivo

1. Induce inflammation and granuloma formation^[1]

Pathogenic mechanism

Trehalose 6,6’-dimycolate prevents calcium-mediated fusion of phagosomes and lysosomes, inhibits phagolysosome acidification, and thereby inhibits the killing effect of mouse macrophages on Mycobacterium tuberculosis, impairs the body's effective immune response, and induces the expression of matrix metalloproteinases.

Specific modeling method

Mice: C57BL/6 female 6-8 week-old (period: 7 days)
Administration: 0.5 or 1.25 mg/kg i.v., or i.p. first then i.v. once

Modeling success index

Phenotypic observation ：Macrophages gather locally, the size and number of granulomas increase, inflammation intensifies, alveolar spaces decrease, there are small hemorrhages, and lymphocytes mainly infiltrate at the junction of granulomas and blood vessels.

Animal Model:	Female C57BL/6 mice (6-8 weeks, 20 g)^[1]
Dosage:	0.5, 1.25 mg/kg (10 μg, 25 μg per 20 g mice)
Administration:	Intravenous injection (i.v.) once (0.5, 1.25 mg/kg), or received 0.5 mg/kg via Intraperitoneal injection (i.p.) followed by an i.v. after 7 days of 0.5 mg/kg
Result:	Increased the lung weight index (LWI). Local aggregation of macrophages was observed 7 days later at 0.5 mg/kg. The size and number of granulomas increased, inflammation intensified, alveolar spaces decreased, small hemorrhagic petechiae appeared, and lymphocytes mainly infiltrated at the intersection of granulomas and blood vessels at 1.25 mg/kg. In i.p.+i.v. model, the inflammatory response was more aggressive. Induced vascular remodeling and collagen deposition.

References

[1] Hwang SA, et al. Mycobacterial trehalose 6,6'-dimycolate induced vascular occlusion is accompanied by subendothelial inflammation. Tuberculosis (Edinb). 2019 May;116S:S118-S122. DOI:10.1016/j.tube.2019.04.019
[2] Welsh KJ, et al. Trehalose 6,6'-dimycolate--a coat to regulate tuberculosis immunopathogenesis. Tuberculosis (Edinb). 2013 Dec;93 Suppl:S3-9. DOI:10.1016/S1472-9792(13)70003-9

Preparation Products And Raw materials

Trehalose 6,6'-dimycolate Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Xiya Chemical Co., Ltd	13355009207 13355009207	3007715519@qq.com	China	18722	57
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29977	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	87240	60
Chengdu Huachun Technology Co., Ltd	400-1166-196 15982826727	cdhxsj@163.com	China	14571	60
Shanghai Zhen Li Biological Technology Co., Ltd	021-16621358918; 18516310516;16621358918;13045646768	zhenlipharma888@163.com	China	19060	58
BOC Sciences	16314854226	inquiry@bocsci.com	United States	9713	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19935	58
Shanghai Maclean Biochemical Technology Co., LTD	021-50706066 15221275939	shenlinxing@macklin.cn	China	29676	58
Shanghai Haohong Scientific Co., Ltd.	400-8210725 4008210725	malulu@leyan.com	China	39771	58

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