Description
Bambuterol is an inactive prodrug of terbutaline. It has a prolonged duration
of action when administered orally.
Chemical Properties
White Solid
Uses
Ester prodrug of the 2-adrenergic agonist terbutaline.
Uses
Ester prodrug of the -adrenergic agonist terbutaline
Uses
beta adrenergic agonist, bronchodilator, cholinesterase inhibitor
Definition
ChEBI: The hydrochloride salt of bambuterol. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline.
Synthesis
Conventionally, as a method for preparing bambuterol hydrochloride, bis-3,5- (N, N-dimethylcarba) is subjected to an acylation process from 3 ′, 5′-dihydroxyacetophenone represented by the following reaction formula in US Pat. No. 4419364. Preparing moyloxy) -acetophenone (step 1); Preparing a bis-3 ′, 5 ′-(N, N-dimethylcarbamoyloxy) -2-bromo-acetophenone therefrom (step 2); Preparing an bis-3 ′, 5 ′-(N, N-dimethylcarbamoyloxy) -2- (N-benzyl tert-butyl) amino-acetophenone from the alkylation process therefrom (step 3); From this step to prepare a 1- [bis- (3 ', 5'-N, N-dimethylcarbamoyloxy) phenyl] -2-N-3 tert-butylaminoethanol hydrochloride, ie bambuterol hydrochloride.
