Description
Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate (LNO
2; ), cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. LNO
2 isomers serve as potent endogenous ligands for PPARγ and can also decompose or be metabolized to release nitric oxide. 9-Nitrooleate is one of two regioisomers of nitrooleate, the other being 10-nitrooleate (OA-NO
2; used for the mixture of isomers), which are formed by nitration of oleic acid in approximately equal proportions
in vivo. Peroxynitrite, acidified nitrite, and myeloperoxidase in the presence of H
2O
2 and nitrite, all mediate the nitration of oleic acid. OA-NO
2 is found in human plasma as the free acid and esterified in phospholipids at concentrations of 619 ± 52 nM and 302 ± 369 nM, respectively. OA-NO
2 activates PPARγ approximately 7-fold at a concentration of 1 μM and effectively promotes the differentiation of 3T3-L1 preadiopcytes to adipocytes at 3 μM.
Uses
9-Nitrooleic Acid is a bioactive, nitric-oxide derived fatty acid. 9-Nitrooleic Acid thats acts as an irreversible inhibitor of xanthine oxidoreductase. 9-Nitrooleic Acid is a novel antagonist of Ang II-induced hypertension. 9-Nitrooleic Acid is an endogenous PPAR agonist which may offer an effective and safe therapeutic intervention for obesity and obesity-related conditions.
Uses
9-Nitrooleic Acid is a bioactive, nitric-oxide derived fatty acid. 9-Nitrooleic Acid
II-induced hypertension. 9-Nitrooleic Acid is an endogenous PPAR agonist which may offer an effective and safe therapeutic intervention for obesity and obesity-related conditions.
Definition
ChEBI: (9E)-9-nitrooctadecenoic acid is a nitro fatty acid that is (9E)-octadec-9-enoic (elaidic) acid substituted by a nitro group at position 9. It has a role as a human metabolite. It is a long-chain fatty acid, a monounsaturated fatty acid and a nitro fatty acid. It is functionally related to an elaidic acid.
