7-Deaza-2'-C-ethynyladenosine

Uses

NITD008 is an adenosine nucleoside analogue that inhibits proliferation of EV71, which is one of the major causative agents of Hand-Foot-Mouth Disease.

Biological Activity

NITD008 is a selective inhibitor of flaviviruses including dengue virus (EC50 = 0.64 μM), hepatitis C virus and Zika virus, and has also been shown to inhibit tick-borne flaviviruses in vitro. NITD008 has been reported to inhibit RNA-dependent RNA polymerase (RdRp), an essential protein of RNA viruses.

storage

Store at -20°C