Description
Palmitic acid-
13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively. Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid bilayer and trafficking of intracellular proteins, promotes protein-vesicle interactions, and regulates various G protein-coupled receptor functions. Red blood cell palmitic acid levels are increased in patients with metabolic syndrome compared to patients without metabolic syndrome and are also increased in the plasma of patients with type 2 diabetes compared to individuals without diabetes.
Uses
Hexadecanoic-1-13C Acid is a labeled analog of Palmitic Acid (P144500), which is a common fatty acid found in plants and animals. The body converts excess carbohydrates into Palmitic Acid, thus Palmitic Acid is the first fatty acid produced during fatty acid synthesis as well as a precursor for longer fatty acids.
References
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10.1007/s00018-019-03092-7[2] M J SANTOS. Influence of dietary supplementation with fish on plasma fatty acid composition in coronary heart disease patients.[J]. Annals of Nutrition and Metabolism, 1995, 39 1: 52-62. DOI:
10.1159/000177842[3] LUN-ZHAO YI. Plasma fatty acid metabolic profiling and biomarkers of type 2 diabetes mellitus based on GC/MS and PLS-LDA[J]. FEBS Letters, 2006, 580 30: 6837-6845. DOI:
10.1016/j.febslet.2006.11.043[4] EDMOND K KABAGAMBE. Erythrocyte fatty acid composition and the metabolic syndrome: a National Heart, Lung, and Blood Institute GOLDN study.[J]. Clinical chemistry, 2008: 154-162. DOI:
10.1373/clinchem.2007.095059
