2-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-ol

Synthesis

2-[4-(4-nitrophenyl)piperazin-1-yl]ethanol (3.6 g, 14.3 mmol) was used as a starting material and dissolved in methanol (40 mL). To this solution was added palladium/carbon catalyst (700 mg) and the reaction mixture was stirred at 0 °C overnight. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford the target product 2-[4-(4-aminophenyl)piperazin-1-yl]ethanol (2.8 g, 88% yield) as a yellow solid.

References

[1] Patent: WO2015/27222, 2015, A2. Location in patent: Paragraph 0323
[2] Patent: WO2012/59932, 2012, A1. Location in patent: Page/Page column 113
[3] Journal of Medicinal Chemistry, 2005, vol. 48, # 7, p. 2371 - 2387
[4] Patent: US2004/87575, 2004, A1
[5] Patent: US2003/13708, 2003, A1